High ischemia-modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis.

نویسندگان

  • Didier Borderie
  • Yannick Allanore
  • Christophe Meune
  • Jean Y Devaux
  • Ohvanesse G Ekindjian
  • André Kahan
چکیده

Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am J Obstet Gynecol 2002;186:158–66. 12. Redman CWG, Sacks GP, Sargent IL. Preeclampsia, an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 1999;180:499– 506. 13. Smarason AK, Sargent IL, Starkey PM, Redman CWG. The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro. Br J Obstet Gynaecol 1993;100:943–9. 14. Knight M, Redman CWG, Linton EA, Sargent IL. Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies. Br J Obstet Gynaecol 1998;105:632–40. 15. Gupta AK, Rusterholz C, Huppertz B, Malek A, Schneider H, Holzgreve W, et al. A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells. Placenta 2004; in press. 16. Lo YMD, Leung TN, Tein MS, Sargent IL, Zhang J, Lau TK, et al. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin Chem 1999;45:184–8. 17. Zhong XY, Laivuori H, Livingston JC, Ylikorkala O, Sibai BM, Holzgreve W, et al. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol 2001;184:414–9. 18. Shibasaki T, Odagiri E, Shizume K, Ling N. Corticotropin-releasing factor-like activity in human placental extracts. J Clin Endocrinol Metab 1982;55: 384–6. 19. Ng EK, Leung TN, Tsui NB, Lau TK, Panesar NS, Chiu RW, et al. The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia. Clin Chem 2003;49:727–31. 20. Li Y, Zhong XY, Kang A, Troeger C, Holzgreve W, Hahn S. Inability to detect cell free fetal DNA in the urine of normal pregnant women nor in those affected by preeclampsia associated HELLP syndrome. J Soc Gynecol Investig 2003;10:503–8. 21. Huppertz B, Kingdom J, Caniggia I, Desoye G, Black S, Korr H, et al. Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation. Placenta 2003;24:181–90.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Clinical Significance of Ischemia-Modified Albumin in the Diagnosis of Doxorubicin-Induced Myocardial Injury in Breast Cancer Patients

BACKGROUND Ischemia-modified albumin is an altered serum albumin that forms under conditions of oxidative stress, a state also associated with doxorubicin-induced myocardial injury. OBJECTIVE The aim of this study was to better assess diagnostic and prognostic significance of ischemia-modified albumin in patients with breast cancer undergoing doxorubicin chemotherapy. METHODS Blood samples ...

متن کامل

Cord Blood Ischemia Modified Albumin May Predict the Oxidative Stress In Newborns, a Prospective Study in Kolkata

BackgroundPreeclampsia is an ischemic condition which increases the maternal oxidative stress. Babies may born to the preeclamptic mothers with appropriate birth weight and gestational age. Studies about the oxidative stress in those babies are scrace. Materials and methods45 preeclamptic and 40 normal mothers were selected for the study. Cases and controls were age matched. Ischemia modified a...

متن کامل

Glycation abolishes the cardioprotective effects of albumin during ex vivo ischemia‐reperfusion

Hyperglycemia-induced oxidative stress plays a key role in the onset/progression of cardiovascular diseases. For example, it can trigger formation of advanced glycation end (AGE) products with ischemia-reperfusion performed under hyperglycemic conditions. For this study, we hypothesized that albumin modified by glycation loses its unique cardioprotective properties in the setting of ischemia-re...

متن کامل

Evaluation of imprecision for analysis of short tandem repeats by use of mixed blood cells in variable concentrations.

sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis. Am J Med 2004;116:595–600. 20. Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia modified albumin as measured by the albumin cobalt binding test after a marathon race. Clin Chem 2002;48:1097–100. 21. Edwards SW, Hallett M...

متن کامل

Ischemia Modified Albumin as an Acute - Phase Reactant

mean concentration of 0.63 mmol/L, is a powerful acute phase reactant as it changes dramatically during vascular injury and inflammatory processes5. Albumin acts as a buffering agent for endogenous or exogenous toxic molecules due to its various ligands binding ability4,5. The biochemical mechanisms modifying the amino-terminal region of albumin during ischemia are unclear, but reperfusion afte...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical chemistry

دوره 50 11  شماره 

صفحات  -

تاریخ انتشار 2004